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The best anti-wrinkle cream does a dynamite job of erasing lines and nourishing the skin, in a quick and efficient manner. For optimal results, you want a cream that stays on long enough to penetrate beneath the skin, helping to erase wrinkles and promote glowing skin. Night creams work great for this purpose because it stays on the skin (which has usually been cleansed and toned) all night long, giving the product a chance to work into the skin for a long period. Avoid nighttime products if you have sensitive or oily skin, as you might wake up with red, irritated skin.